Use of alkaline Comet assay to assess DNA repair after m-THPC-PDT.

  title={Use of alkaline Comet assay to assess DNA repair after m-THPC-PDT.},
  author={Nathalie Rousset and E Keminon and Sabine El{\'e}ouet and Tanguy Le N{\'e}el and J L Auget and V Vonarx and J. -Y. Carr{\'e} and Youenn Lajat and Thierry Patrice},
  journal={Journal of photochemistry and photobiology. B, Biology},
  volume={56 2-3},
Photodynamic therapy (PDT) with Photofrin has already been authorized for certain applications in Japan, the USA and France, and powerful second-generation sensitizers such as meta-(tetrahydroxyphenyl) chlorin (m-THPC) are now being considered for approval. Although sensitizers are likely to localize within the cytoplasm or the plasma membrane, nuclear membrane can be damaged at an early stage of photodynamic reaction, resulting in DNA lesions. Thus, it is of critical importance to assess the… CONTINUE READING


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