Use of acetazolamide as an adjunct to carbamazepine in refractory partial seizures.

@article{Oles1989UseOA,
  title={Use of acetazolamide as an adjunct to carbamazepine in refractory partial seizures.},
  author={Karen S. Oles and J. Kiffin Penry and Desiree L. Cole and George Howard},
  journal={Epilepsia},
  year={1989},
  volume={30 1},
  pages={74-8}
}
Acetazolamide (Diamox) (AZM) was evaluated as an adjunct to carbamazepine (CBZ) monotherapy in 48 refractory partial seizure patients at a tertiary care referral center. Patient ages ranged from 6 to 64 years (average 28 years). Seizure frequencies for the pre-AZM baseline period (CBZ monotherapy) were compared with the seizure frequencies at different daily doses of AZM. Patients with a 50% decrease in seizure frequency were considered responders. Twenty-one patients were responders (44%) and… CONTINUE READING