Use of a variable alpha region to create a functional T-cell receptor delta chain.

Abstract

Two categories of T-cell antigen-specific receptor have been described. Most mature T lymphocytes have, on their membrane, an antigen receptor consisting of alpha and beta subunits, while early T cells and thymocytes possess a heterodimeric receptor termed gamma-delta. The DS6 clone, isolated from the peripheral blood of a patient with immunodeficiency, is… (More)

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