Use of a soluble epoxide hydrolase inhibitor in smoke-induced chronic obstructive pulmonary disease.

@article{Wang2012UseOA,
  title={Use of a soluble epoxide hydrolase inhibitor in smoke-induced chronic obstructive pulmonary disease.},
  author={Lei Wang and Jun Yang and Lei Guo and Dale L. Uyeminami and Hua Dong and Bruce D Hammock and Kent E Pinkerton},
  journal={American journal of respiratory cell and molecular biology},
  year={2012},
  volume={46 5},
  pages={614-22}
}
Tobacco smoke-induced chronic obstructive pulmonary disease (COPD) is a prolonged inflammatory condition of the lungs characterized by progressive and largely irreversible airflow limitation attributable to a number of pathologic mechanisms, including bronchitis, bronchiolitis, emphysema, mucus plugging, pulmonary hypertension, and small-airway obstruction. Soluble epoxide hydrolase inhibitors (sEHIs) demonstrated anti-inflammatory properties in a rat model after acute exposure to tobacco smoke… CONTINUE READING