Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures

@inproceedings{Du2015UseOA,
  title={Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures},
  author={Zhimei Du and David L Treiber and John D. McCarter and Dina Fomina-Yadlin and Ramsey A. Saleem and Rebecca E McCoy and Yuling Zhang and Tharmala Tharmalingam and Matthew Leith and Brian D. Follstad and Brad Dell and Brent Grisim and Craig Zupke and Carole Heath and Arvia E. Morris and P. Chandrashekar Reddy},
  booktitle={Biotechnology and bioengineering},
  year={2015}
}
The continued need to improve therapeutic recombinant protein productivity has led to ongoing assessment of appropriate strategies in the biopharmaceutical industry to establish robust processes with optimized critical variables, that is, viable cell density (VCD) and specific productivity (product per cell, qP). Even though high VCD is a positive factor for titer, uncontrolled proliferation beyond a certain cell mass is also undesirable. To enable efficient process development to achieve… CONTINUE READING
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The effect of bioreactor pH and temperature on protein glycosylation in perfusion cultures of mammalian cells

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