Use of a platelet-fibrinogen-thrombin mixture as a corneal adhesive: experiments with sutureless lamellar keratoplasty in the rabbit.

@article{Rosenthal1975UseOA,
  title={Use of a platelet-fibrinogen-thrombin mixture as a corneal adhesive: experiments with sutureless lamellar keratoplasty in the rabbit.},
  author={A. Ralph Rosenthal and Christina Harbury and Peter R. Egbert and Edward Rubenstein},
  journal={Investigative ophthalmology},
  year={1975},
  volume={14 11},
  pages={872-5}
}
A platelet-fibrinogen-thrombin mixture utilizing autologous platelets was studied for its potential as a corneal adhesive. In the rabbit it demonstrated sufficient adhesive properties to allow 50 per cent of lamellar keratoplasties (autotransplants) to remain in place without the use of sutures. The mixture retains significant adhesive properties for four to six days. It is simple to prepare and apply. It also appears nonantigenic and nontoxic to the cornea; it does not incite inflammation, nor… CONTINUE READING

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