Use of a patch containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: a phase II, randomised, double-blind, placebo-controlled field trial.

@article{Frech2008UseOA,
  title={Use of a patch containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: a phase II, randomised, double-blind, placebo-controlled field trial.},
  author={Sarah A Frech and H L DuPont and August Louis Bourgeois and Robin McKenzie and Jaime Belkind-Gerson and Jose Flores Figueroa and Pablo C Okhuysen and Norma H Guerrero and Francisco G Martinez-Sandoval and Juan Hm Mel{\'e}ndez-Romero and Z D Jiang and Edwin Jose Asturias and Jane L Halpern and Olga R. Torres and Ana S Hoffman and Christina P Villar and Raniya N Kassem and David C Flyer and Bo H Andersen and Kazem Kazempour and Sally A Breisch and Gregory Melvin Glenn},
  journal={Lancet},
  year={2008},
  volume={371 9629},
  pages={2019-25}
}
BACKGROUND Enterotoxigenic Escherichia coli (ETEC) is a major cause of travellers' diarrhoea. We investigated the rate of diarrhoea attacks, safety, and feasibility of a vaccine containing heat-labile enterotoxin (LT) from ETEC delivered to the skin by patch in travellers to Mexico and Guatemala. METHODS In this phase II study, healthy adults (aged 18-64 years) who planned to travel to Mexico or Guatemala and had access to a US regional vaccination centre were eligible. A centralised… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

Delivery systems for intradermal vaccination.

Current topics in microbiology and immunology • 2012
View 4 Excerpts
Highly Influenced

Recent advances in understanding enteric pathogenic Escherichia coli.

Clinical microbiology reviews • 2013
View 16 Excerpts
Highly Influenced

Mucosal immune responses induced by transcutaneous vaccines.

Current topics in microbiology and immunology • 2012
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…