Use of a novel floxed mouse to characterise the cellular source of plasma coagulation FXIII-A.

@article{Griffin2015UseOA,
  title={Use of a novel floxed mouse to characterise the cellular source of plasma coagulation FXIII-A.},
  author={Kathryn Jane Griffin and Kingsley R. Simpson and Cora M. L. Beckers and Jane M. Brown and Jean Vacher and Wilhelm Ouwehand and Warren S. Alexander and Richard J. Pease and Peter J. Grant},
  journal={Lancet},
  year={2015},
  volume={385 Suppl 1},
  pages={S39}
}
BACKGROUND Coagulation factor XIII-A has a crucial role in thrombus stabilisation and tissue repair. Factor XIII-A deficiency causes a severe bleeding phenotype and impaired wound healing, but the cellular origin of Factor XIII-A is unknown. To identify the cells that maintain the plasma pool, we generated a mouse floxed in coding exon7 of the factor XIII-A gene (F13A1). These mice were crossed with mice transgenic for Pf4-Cre-recombinase (thrombopoietic deletion) or Cd11b-Cre-recombinase… CONTINUE READING