Use of a new mouse model of Acinetobacter baumannii pneumonia to evaluate the postantibiotic effect of imipenem.

@article{JolyGuillou1997UseOA,
  title={Use of a new mouse model of Acinetobacter baumannii pneumonia to evaluate the postantibiotic effect of imipenem.},
  author={Marie-laure Joly-Guillou and Michel Wolff and J. J. Pocidalo and Francine Walker and Claude Carbon},
  journal={Antimicrobial agents and chemotherapy},
  year={1997},
  volume={41 2},
  pages={345-51}
}
Acinetobacter baumannii is responsible for severe nosocomial pneumonia. To evaluate new therapeutic regimens for infections due to multiresistant strains and to study the pharmacodynamic properties of various antibiotics, we developed an experimental mouse model of acute A. baumannii pneumonia. C3H/HeN mice rendered transiently neutropenic were infected intratracheally with 5 x 10(6) CFU of A. baumannii. The mean log10 CFU/g of lung homogenate (+/- the standard deviation) were 9 +/- 0.9, 9.4… CONTINUE READING