Use of a cDNA microarray to analyse gene expression patterns in human cancer

@article{Derisi1996UseOA,
  title={Use of a cDNA microarray to analyse gene expression patterns in human cancer},
  author={Joseph L. Derisi and Lolita K. Penland and Patrick O. Brown and Michael L. Bittner and Paul S. Meltzer and Michael E. Ray and Yidong Chen and Y. A. Su and Jeffrey M. Trent},
  journal={Nature Genetics},
  year={1996},
  volume={14},
  pages={457-460}
}
The development and progression of cancer1–3 and the experimental reversal of tumorigenicity4,5 are accompanied by complex changes in patterns of gene expression. Microarrays of cDNA provide a powerful tool for studying these complex phenomena6–8. The tumorigenic properties of a human melanoma cell line, UACC-903, can be suppressed by introduction of a normal human chromosome 6, resulting in a reduction of growth rate, restoration of contact inhibition, and suppression of both soft agar… Expand
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