Use of a bisphosphonate (pamidronate) to modulate fracture repair in ovine bone.

@article{Goodship1994UseOA,
  title={Use of a bisphosphonate (pamidronate) to modulate fracture repair in ovine bone.},
  author={Allen E Goodship and Paul Charles Walker and Derek McNally and Tim Chambers and Jonathan R. Green},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={1994},
  volume={5 Suppl 7},
  pages={S53-5}
}
Bisphosphonates influence the morphology and mechanical properties of bones in growing rats, but their effects on fracture repair are not well documented. This study tests the hypothesis that bisphosphonates will modulate the remodelling phase of fracture repair, influencing the mechanical properties of healing bone. The effects of a bisphosphonate (pamidronate, Aredia) on the healing of a 3 mm osteotomy gap in the mid-diaphysis of the tibia, under rigid unilateral external fixation, were… CONTINUE READING