Use of a WHO-recommended algorithm to reduce mortality in seriously ill patients with HIV infection and smear-negative pulmonary tuberculosis in South Africa: an observational cohort study.

@article{Holtz2011UseOA,
  title={Use of a WHO-recommended algorithm to reduce mortality in seriously ill patients with HIV infection and smear-negative pulmonary tuberculosis in South Africa: an observational cohort study.},
  author={Timothy H Holtz and Ga{\"e}tan M. Kabera and Thuli Mthiyane and Tainos Zingoni and Sidhambaram Nadesan and Douglas J. Monterey Ross and Jennifer Allen and Sekai Chideya and Henry Sunpath and Roxana Rustomjee},
  journal={The Lancet. Infectious diseases},
  year={2011},
  volume={11 7},
  pages={533-40}
}
BACKGROUND In 2007, WHO released revised recommendations and an algorithm for the diagnosis and treatment of smear-negative pulmonary tuberculosis in seriously ill people living with HIV/AIDS. We aimed to assess the effect of the recommendations on clinical outcome in patients in South Africa. METHODS We enrolled seriously ill patients (aged ≥15 years) with HIV infection and suspected smear-negative pulmonary tuberculosis from three hospitals in KwaZulu-Natal, South Africa. Patients were… CONTINUE READING
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