Use of a T cell interferon-gamma release assay to evaluate tuberculosis risk in newly qualified physicians in Singapore healthcare institutions.

@article{Chee2009UseOA,
  title={Use of a T cell interferon-gamma release assay to evaluate tuberculosis risk in newly qualified physicians in Singapore healthcare institutions.},
  author={Cynthia Bin-Eng Chee and Linda Y. Y. Lim and Timothy Mark Sebastian Barkham and Dow Rhoon Koh and Stephen Lam and Liang Shen and Yee Tang Sonny Wang},
  journal={Infection control and hospital epidemiology},
  year={2009},
  volume={30 9},
  pages={870-5}
}
BACKGROUND Surveillance for latent tuberculosis in high-risk groups such as healthcare workers is limited by the nonspecificity of the tuberculin skin test (TST) in BCG-vaccinated individuals. The Mycobacterium tuberculosis antigen-specific interferon-gamma release assays (IGRAs) show promise for more accurate latent tuberculosis detection in such groups. OBJECTIVE To compare the utility of an IGRA, the T-SPOT.TB assay, with that of the TST in healthcare workers with a high rate of BCG… CONTINUE READING
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