Use of a Drosophila Genome-Wide Conserved Sequence Database to Identify Functionally Related cis-Regulatory Enhancers

@inproceedings{Brody2012UseOA,
  title={Use of a Drosophila Genome-Wide Conserved Sequence Database to Identify Functionally Related cis-Regulatory Enhancers},
  author={Thomas Brody and Amarendra S. Yavatkar and Alexander Kuzin and Mukta Kundu and Leonard J. Tyson and Jermaine Ross and Tzu-Yang Lin and C Lee and Takeshi Awasaki and Tzumin Lee and Ward F Odenwald},
  booktitle={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2012}
}
BACKGROUND Phylogenetic footprinting has revealed that cis-regulatory enhancers consist of conserved DNA sequence clusters (CSCs). Currently, there is no systematic approach for enhancer discovery and analysis that takes full-advantage of the sequence information within enhancer CSCs. RESULTS We have generated a Drosophila genome-wide database of conserved DNA consisting of >100,000 CSCs derived from EvoPrints spanning over 90% of the genome. cis-Decoder database search and alignment… CONTINUE READING
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