Use of Vaxfectin adjuvant with DNA vaccine encoding the measles virus hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques against measles virus.

@article{Pan2008UseOV,
  title={Use of Vaxfectin adjuvant with DNA vaccine encoding the measles virus hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques against measles virus.},
  author={Chien-Hsiung Pan and Gretchen S. Jimenez and Nitya Nair and Qun Wei and Robert J. Adams and Fernando P Polack and Alain Nicolas Rolland and Adri{\'a}n Vilalta and Diane E Griffin},
  journal={Clinical and vaccine immunology : CVI},
  year={2008},
  volume={15 8},
  pages={
          1214-21
        }
}
A measles virus vaccine for infants under 6 months of age would help control measles. DNA vaccines hold promise, but none has provided full protection from challenge. Codon-optimized plasmid DNAs encoding the measles virus hemagglutinin and fusion glycoproteins were formulated with the cationic lipid-based adjuvant Vaxfectin. In mice, antibody and gamma interferon (IFN-gamma) production were increased by two- to threefold. In macaques, juveniles vaccinated at 0 and 28 days with 500 microg of… CONTINUE READING
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