Use of Tissue Sealants in Face-Lifts: A Metaanalysis

  title={Use of Tissue Sealants in Face-Lifts: A Metaanalysis},
  author={Yong Chen Por and Luming Shi and Miny Samuel and Colin Song and Vincent Kok Leng Yeow},
  journal={Aesthetic Plastic Surgery},
BackgroundThis review sought to determine the efficacy of tissue sealants such as fibrin tissue adhesives and platelet-rich plasma in reducing postoperative drainage, ecchymosis, and edema after face-lift surgery.MethodsThe electronic databases MEDLINE (1966–May 2007) and EMBASE (1974–May 2007) and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched for human studies, randomized controlled trials, controlled clinical trials, metaanalyses, and reviews of randomized… 
Tissue sealants may reduce haematoma and complications in face-lifts: A meta-analysis of comparative studies.
A systematic examination of the effect of tissue glues on rhytidectomy complications.
It is suggested that fibrin glue reduces the rates of hematoma formation, but does not significantly reduce the ratesof seroma development.
Fibrin tissue adhesive for face- and necklift.
  • M. Berry, J. Stanek
  • Medicine
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • 2015
Methods for Minimizing Bleeding in Facelift Surgery: An Evidence-based Review
Perioperative medical management of blood pressure, tissue sealants, and tranexamic acid are most effective in facilitating hemostasis and preventing postoperative hematoma in facelift surgery.
Efficacy and Safety of Artiss Fibrin Tissue Sealant Use in Rhytidectomy: A Review of 120 Cases
Artiss is efficacious and safe for use in rhytidectomies, and complications are minimal and similar in rate to the use of Tisseel.
Efficacy and safety of fibrin sealant for tissue adherence in facial rhytidectomy
  • W. Spotnitz
  • Medicine
    Clinical, cosmetic and investigational dermatology
  • 2012
Fibrin sealant is almost ideally suited to reduce the occurrence of fluid accumulation, hematomas, ecchymoses, and swelling, as well as to possibly eliminate the need for drains following rhytidectomy.
Is fibrin sealant effective and safe in total knee arthroplasty? A meta-analysis of randomized trials
The present meta-analysis indicates that the use of fibrin sealant was effective and safe as a hemostatic therapy for patients with TKA.
The Role of the Superwet Technique in Face Lift: An Analysis of 1089 Patients over 23 Years
This analysis showed excellent outcomes with a hematoma rate of 0.9 percent and the authors attribute their consistent and reproducible results to the use of the superwet technique and platelet-rich plasma.
Quilting Sutures in Rhytidectomy: A Systematic Review of the Literature.
QS can be applied either internally or externally and are very effective in reducing hematomas after facelifts and should be used with caution as additional work is needed to confirm its safety and efficacy.
A Systematic Review of Comparison of Efficacy and Complication Rates among Face-Lift Techniques
The need for better studies, especially randomized, prospective, controlled studies, and a need for a standardized method of efficacy analysis and patient-reported outcomes measures to allow objective comparison of face-lift techniques are shown.


Early postoperative efficacy of fibrin glue in face lifts: a prospective randomized trial.
It is suggested that fibrin glue may not be as beneficial as previously thought in reducing ecchymosis and edema in the early postoperative period after face lifts, and its future role is discussed.
A prospective, randomized, double-blind trial of the use of fibrin sealant for face lifts.
The reduction in postoperative drainage could also reduce pain and bruising, increasing patient satisfaction with this procedure, and the need for drains may also be obviated.
The Efficacy of Surgical Drainage in Cervicofacial Rhytidectomy: A Prospective, Randomized, Controlled Trial
Surgical drains do not influence postoperative complications, but they do significantly reduce bruising and so may facilitate the patient's return to normal activity, representing the first prospective, randomized, controlled trial assessing the use of postoperative drainage in facial rejuvenation surgery.
Recovery from deep-plane rhytidectomy following unilateral wound treatment with autologous platelet gel: a pilot study.
Treatment with APG may prevent or improve edema or ecchymosis after deep-plane rhytidectomy, and is chiefly demonstrable in the early phases of recovery.
Surgical tissue adhesives.
Avoiding Hematoma in Cervicofacial Rhytidectomy: A Personal 8-Year Quest. Reviewing 910 Patients
Although many of the suggested ancillary methods used to reduce hematoma did not produce any statistical reduction in the incidence of this complication, the exclusion of adrenaline had a profound effect.
Is platelet-rich plasma the perfect enhancement factor? A current review.
Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing.
A variety of potentially therapeutic growth factors were detected and released from the platelets in significant levels in platelet-rich plasma preparations and may be capable of expediting wound healing in a variety of as yet undetermined specific wound applications.
a prospective randomized, controlled trial
  • Plast Reconstr Surg 120:263–270 Table 5 Postoperative edema at 7–8 days: tissue sealant versus control, as expressed by weighted mean difference Aesth Plast Surg
  • 2009