Use of TK-cells in haploidentical hematopoietic stem cell transplantation.

Abstract

PURPOSE OF REVIEW Preserving the beneficial effects of donor T cells against tumor and pathogens while avoiding noxious graft-versus-host disease (GvHD) is the 'holy grail' of allogeneic hematopoietic stem cell transplantation (HSCT). The suicide gene strategy allows the selective elimination of genetically modified donor T cells during GvHD. This review… (More)
DOI: 10.1097/MOH.0b013e32835822f5

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