Use of T cell-based diagnosis of tuberculosis infection to optimize interpretation of tuberculin skin testing for child tuberculosis contacts.

@article{Bakir2009UseOT,
  title={Use of T cell-based diagnosis of tuberculosis infection to optimize interpretation of tuberculin skin testing for child tuberculosis contacts.},
  author={Mustafa Bakir and Davinder P. S. Dosanjh and Jonathan J. Deeks and Ahmet Soysal and Kerry A. Millington and S Cumali Efe and Yasemin Aslan and Dilek Polat and Nihat Kodalli and Aysegul Karahasan Yagci and Isil Berat Barlan and Nerin Nadir Bahçeciler and Emel Ekşioğlu Demiralp and Ajit Lalvani},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2009},
  volume={48 3},
  pages={302-12}
}
BACKGROUND Treatment of recent tuberculosis infection in children aged <2 years is essential, because of high risk of progression to disease, but diagnosis is hindered by the inaccuracy of the tuberculin skin test (TST). More-accurate T cell-based tests of infection could enhance diagnosis by optimizing interpretation of the TST results. METHODS A total of 979 child tuberculosis contacts in Istanbul underwent the TST and enzyme-linked immunospot assay. Using enzyme-linked immunospot test… CONTINUE READING

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Prognostic value of a T-cell–based, interferon-g biomarker in Turkish children—authors’ response

A. Lalvani
Ann Intern Med 2008; published online 7 November. Available at: http://www.annals.org/cgi/eletters/149/11/777. Accessed • 2008
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