Use of Synthetic Oligonucleotides in the Characterization of Antithrombin HI Northwick Park ( 393 CGT -

  • Published 2005

Abstract

Antithrombin Ill (ATIII) Northwick Park is caused by a single amino acid substitution, Arg 393 -‘ Cys and antithrombin III Glasgow is caused by Arg 393 -#{247} His. Examination of the genetic code and the sequence of normal antithrombin Ill revealed that these amino acid substitutions could arise from the substitution of either two nucleotides or a single nucleotide at codon 393 of the antithrombin III gene. In two families. detection of the ATIII variants by genetic linkage analysis was not possible owing to lack of informative RFLP markers. Consequently. we synthesized two 22-base-long

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Cite this paper

@inproceedings{2005UseOS, title={Use of Synthetic Oligonucleotides in the Characterization of Antithrombin HI Northwick Park ( 393 CGT -}, author={}, year={2005} }