Use of Streptozotocin in Rodent Models of Islet Transplantation.

  title={Use of Streptozotocin in Rodent Models of Islet Transplantation.},
  author={Aileen J.F. King and Elisabet Estil les and Eduard Montanya},
  journal={Methods in molecular biology},
Streptozotocin (STZ) selectively destroys beta cells and is widely used to induce experimental diabetes in rodents. Rodent beta cells are very sensitive to the toxic effects of STZ, while human beta cells are highly resistant to STZ. Taking advantage of this characteristic, here, we describe two protocols for the induction of STZ-diabetes. In the first model, hyperglycemia is induced prior to islet transplantation, whereas in the second model, STZ is injected after islet transplantation. The… 
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