Use of RNA interference to target cyclin E-overexpressing hepatocellular carcinoma.

@article{Li2003UseOR,
  title={Use of RNA interference to target cyclin E-overexpressing hepatocellular carcinoma.},
  author={Kaiyi Li and Shiaw-Yih Lin and Francis Charles Brunicardi and Philip Seu},
  journal={Cancer research},
  year={2003},
  volume={63 13},
  pages={3593-7}
}
RNA interference is the process by which double-stranded RNA directs sequence-specific degradation of mRNA. It has recently been shown that RNA interference can be triggered by 21-nucleotide duplexes of small interfering RNAs (siRNAs) in both cultured mammalian cells and adult mice. We hypothesize that siRNA can be used to specifically target oncogene… CONTINUE READING