Use of PET and the radioligand [carbonyl-(11)C]WAY-100635 in psychotropic drug development.

  title={Use of PET and the radioligand [carbonyl-(11)C]WAY-100635 in psychotropic drug development.},
  author={Bengt A. Andr{\'e}e and Christer Halldin and S O Thorberg and Johan Sandell and Lars Farde},
  journal={Nuclear medicine and biology},
  volume={27 5},
Positron-emission tomography (PET) provides potential in neuropsychiatric drug development by expanding knowledge of drug action in the living human brain and reducing time consumption and costs. The 5-hydroxytryptamine(1A) (5-HT(1A)) receptor is of central interest as a target for the treatment of anxiety, depression, and schizophrenia. Research on the clinical significance of the 5-HT(1A) receptor now benefits from the highly selective radioligand [carbonyl-(11)C]WAY-100635 (WAY) for… CONTINUE READING


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