Use of OpdA, an organophosphorus (OP) hydrolase, prevents lethality in an African green monkey model of acute OP poisoning.

@article{Jackson2014UseOO,
  title={Use of OpdA, an organophosphorus (OP) hydrolase, prevents lethality in an African green monkey model of acute OP poisoning.},
  author={Colin J Jackson and Angela Carville and Jeanine A Ward and Keith G Mansfield and David L. Ollis and Tejvir S Khurana and Steven B Bird},
  journal={Toxicology},
  year={2014},
  volume={317},
  pages={
          1-5
        }
}
Organophosphorus (OP) pesticides are a diverse class of acetylcholinesterase (AChE) inhibitors that are responsible for tremendous morbidity and mortality worldwide, killing approximately 300,000 people annually. Enzymatic hydrolysis of OPs is a potential therapy for acute poisoning. OpdA, an OP hydrolase isolated from Agrobacterium radiobacter, has been shown to decrease lethality in rodent models of OP poisoning. This study investigated the effects of OpdA on AChE activity, plasma… CONTINUE READING
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