Use of Multiplex Ligation-Dependent Probe Amplification (MLPA) in screening of subtelomeric regions in children with idiopathic mental retardation.

@article{Mandal2009UseOM,
  title={Use of Multiplex Ligation-Dependent Probe Amplification (MLPA) in screening of subtelomeric regions in children with idiopathic mental retardation.},
  author={Kausik Mandal and Vijay Raju Boggula and Minal Borkar and Suraksha Agarwal and Shubha R. Phadke},
  journal={Indian journal of pediatrics},
  year={2009},
  volume={76 10},
  pages={1027-31}
}
OBJECTIVE To detect subtelomeric copy number variations (deletions and duplications) using Multiplex Ligation-Dependent Probe Amplification (MLPA) technique in children with idiopathic mental retardation. METHODS All children presenting to the genetics out-patient department for evaluation of mental retardation or developmental delay over a period of two years, for whom no identifiable cause could be found by clinical evaluation, karyotyping, neuroimaging and other relevant investigations… CONTINUE READING