Use of MTHFR C677T polymorphism and plasma pharmacokinetics to predict methotrexate toxicity in patients with acute lymphoblastic leukemia.

@article{Mahmoud2018UseOM,
  title={Use of MTHFR C677T polymorphism and plasma pharmacokinetics to predict methotrexate toxicity in patients with acute lymphoblastic leukemia.},
  author={Lobna Ben Mahmoud and Moez Mdhaffar and Rim Frikha and Hanen Ghozzi and Ahmed Hakim and Zouheir Sahnoun and Moez Elloumi and Khaled Mounir Zeghal},
  journal={Advances in clinical and experimental medicine : official organ Wroclaw Medical University},
  year={2018},
  volume={27 8},
  pages={
          1061-1068
        }
}
  • Lobna Ben Mahmoud, Moez Mdhaffar, +5 authors Khaled Mounir Zeghal
  • Published in
    Advances in clinical and…
    2018
  • Medicine
  • BACKGROUND Methotrexate (MTX) is a key component of acute lymphoblastic leukemia (ALL) therapy, but it is associated with serious toxicities in a considerable number of patients. OBJECTIVES The aim of the current study was to determine which variables were associated with MTX toxicity in children, adolescents and young adults with ALL. MATERIAL AND METHODS In this prospective study, 35 patients with newly diagnosed ALL, treated according to the 58951 European Organization for Research and… CONTINUE READING

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