Use of Ly6G‐specific monoclonal antibody to deplete neutrophils in mice

@article{Daley2008UseOL,
  title={Use of Ly6G‐specific monoclonal antibody to deplete neutrophils in mice},
  author={Jean M. Daley and Alan A. Thomay and Michael D. Connolly and Jonathan S. Reichner and Jorge E. Albina},
  journal={Journal of Leukocyte Biology},
  year={2008},
  volume={83}
}
The anti‐granulocyte receptor‐1 (Gr‐1) mAb, RB6‐8C5, has been used extensively to deplete neutrophils in mice and to investigate the role of these cells in host defense. RB6‐8C5 binds to Ly6G, which is present on neutrophils, and to Ly6C, which is expressed on neutrophils, dendritic cells, and subpopulations of lymphocytes and monocytes. It is thus likely that in vivo administration of RB6‐8C5 may deplete not only neutrophils but also other Gr‐l+ (Ly6C+) cells. This study describes the use of… 

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