Use of L-asparaginase in childhood ALL.

@article{Mueller1998UseOL,
  title={Use of L-asparaginase in childhood ALL.},
  author={Heinz Joachim Mueller and Joachim Boos},
  journal={Critical reviews in oncology/hematology},
  year={1998},
  volume={28 2},
  pages={
          97-113
        }
}
Owing to the high efficacy of L-asparaginase in the treatment of acute lymphatic leukaemia the enzyme was introduced into the chemotherapy schedules for remission induction of this disease shortly after results of large-scale clinical trials had become available. Since asparaginase monotherapy was associated with a high response rate but short remission duration, the enzyme is currently employed within the framework of combination chemotherapy schedules which achieve treatment response in about… CONTINUE READING

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