Use of Intravenous Valproic Acid for Acute Migraine

@article{Frazee2008UseOI,
  title={Use of Intravenous Valproic Acid for Acute Migraine},
  author={Lawrence A. Frazee and Kimberly C Foraker},
  journal={Annals of Pharmacotherapy},
  year={2008},
  volume={42},
  pages={403 - 407}
}
Objective: To review the literature regarding the use of intravenous valproic acid in aborting an acute migraine attack. Data Sources: A MEDLINE (1967–June 2007) and bibliographic search of the English-language literature was conducted using the search terms valproic acid and migraine disorders. Study Selection and Data Extraction: All articles indentified through the search were included. Data Synthesis: Divalproex sodium is approved by the Food and Drug Administration for the prevention of… 
Intravenous sodium valproate for acute migraine in the emergency department: A meta‐analysis
TLDR
iVPA was inferior to the studied comparators and was comparable to dexamethasone for aborting migraine attack and wasparable to dex amethas one for aborted migraine attack.
Single-dose intravenous sodium valproate (Depakine) versus dexamethasone for the treatment of acute migraine headache: a double-blind randomized clinical trial
TLDR
This randomized clinical trial showed that the intravenous injection of sodium valproate 400 mg has similar effects to those of dexamethasone for improving acute migraine headache.
Effect of Intravenous Sodium Valproate vs Dexamethasone on Acute Migraine Headache: A Double Blind Randomized Clinical Trial
TLDR
It is indicated that, in overall, intravenous sodium valproate is not superior to intravenous dexamethasone in treatment of acute migraine attacks, and in patients with aura, only sodiumvalproate but not dexamETHasone is effective in headache relief.
Randomized Clinical Trial of Intravenous Valproate (Orifil) and Dexamethasone in Patients with Migraine Disorder
TLDR
IVVP (Orifil) was similar in efficacy to IVDEX as abortive therapy in patients with migraine status and appears to offer a safe and well-tolerated abortive treatment.
Acute Confusional Migraine in an Adolescent: Response to Intravenous Valproate
TLDR
The case of a 12-year-old girl who presented with an ACM attack that resolved rapidly after intravenous administration of valproic acid is reported here.
Comprehensive management of adults with chronic migraine: Clinical practice guidelines in Mexico
TLDR
The risk factors and treatments available for the management of CM are identified based on a grading system, which facilitates selection for individualized management and highlights the necessity of managing comorbidities initially.
Italian guidelines for primary headaches: 2012 revised version
TLDR
The first edition of the Italian diagnostic and therapeutic guidelines for primary headaches in adults was published in J Headache Pain 2(Suppl. 1):105–190 in 2001 and a section was dedicated to non-pharmacological treatment.
Urgent Care/Emergency Treatment of the Acute, Severe Headache in Pregnant and Lactating Patients
TLDR
Patients with residual headache after standard treatments may benefit from a greater occipital nerve block and/or a short course of prednisone.
Review of the Typical and Atypical Treatment Options for Acute Migraine Headache in the Emergency Department
  • Lucy Franjic
  • Medicine
    Current Emergency and Hospital Medicine Reports
  • 2016
TLDR
This review focuses on both the typical as well as atypical migraine headache treatment options in emergency departments, taking into account the risks and benefits of each and the population being addressed, aswell as drug availability within the respective institution.
El ácido valproico como agente sensibilizador al tratamiento anticáncer.
TLDR
The metabolism of valproic acid and its application against cancer are analyzed and it is shown that it decreases the frequency of head and neck cancer.
...
1
2
...

References

SHOWING 1-10 OF 29 REFERENCES
Safety and efficacy of intravenous sodium valproate in the treatment of acute migraine.
TLDR
The results confirm the therapeutic value of intravenous Valproate in acute migraine attacks described in literature and show a beneficial effect on all investigated efficacy parameters with a trend to even better response in patients receiving valproate prophylaxis.
Use of Intravenous Valproate Sodium in Status Migraine
TLDR
The oral form of valproic acid has been used as a prophylactic agent, but the intravenous form may provide an alternative for abortive care as well, and double‐blind studies will help clarify the situation.
Intravenous sodium valproate versus prochlorperazine for the emergency department treatment of acute migraine headaches: a prospective, randomized, double-blind trial.
TLDR
Prochlorperazine was statistically and clinically superior to sodium valproate for the treatment of the pain and nausea associated with acute migraine headaches.
Practice parameter: Evidence-based guidelines for migraine headache (an evidence-based review)
TLDR
This practice parameter summarizes the results from the four evidence-based reviews on the management of patients with migraine: specifically, acute, preventive, and nonpharmacologic treatments for migraine, and the role of neuroimaging in patients with headache.
Comparison of Intravenous Valproate Versus Intramuscular Dihydroergotamine and Metoclopramide for Acute Treatment of Migraine Headache
Objective.—To determine the effectiveness and tolerability of intravenous valproate for the acute treatment of migraine headache with or without aura (International Headache Society diagnostic
Comparison of Intravenous Valproate With Intravenous Lysine‐Acetylsalicylic Acid in Acute Migraine Attacks
TLDR
The study compared efficacy and tolerability of intravenous valproate (iVPA) with intravenous lysine‐acetylsalicylic acid (iLAS) in acute migraine attacks with similar results.
Intravenous Valproate Sodium (Depacon) Aborts Migraine Rapidly: A Preliminary Report
TLDR
This study was designed to investigate the efficacy and safety of intravenous valproate in the treatment of acute migraine attacks and found it safe and effective.
Pathophysiology of migraine.
TLDR
The author focuses on the current understanding of migraine genetics and reviews recent data from the neuroimaging and the neurophysiology of migraine, which suggests the acute attack may be the final common expression of more than one type of initiating abnormality.
A Report on the Journal 2004
Cephalalgia has been successful by a number of measures in the last 12 months: our circulation is up particularly through electronic penetration in libraries, our submission rate has risen
Acute Migraine Treatment: Patterns of Use and Satisfaction in a Clinical Population
Background.—The sequence and timing of taking migraine medications, whether prescription or over‐the‐counter, and the patient's response to their treatment, is unknown.
...
1
2
3
...