Use of Intravenous Recombinant Tissue Plasminogen Activator in Patients With Acute Ischemic Stroke Who Take Non-Vitamin K Antagonist Oral Anticoagulants Before Stroke.

@article{Xian2017UseOI,
  title={Use of Intravenous Recombinant Tissue Plasminogen Activator in Patients With Acute Ischemic Stroke Who Take Non-Vitamin K Antagonist Oral Anticoagulants Before Stroke.},
  author={Ying Xian and Jerome J. Federspiel and Adrian F. Hernandez and Daniel T Laskowitz and Lee H Schwamm and Deepak L Bhatt and Eric E Smith and Gregg C Fonarow and Eric D. Peterson},
  journal={Circulation},
  year={2017},
  volume={135 11},
  pages={1024-1035}
}
BACKGROUND Intravenous rt-PA (recombinant tissue-type plasminogen activator) is effective in improving outcomes in ischemic stroke; however, there are few data on the use of rt-PA in patients who are receiving a non-vitamin K antagonist oral anticoagulant (NOAC). METHODS Using data from the American Heart Association Get With The Guidelines-Stroke Registry, we examined the outcomes of use of thrombolytic therapy in patients with ischemic stroke who received anticoagulation with NOACs versus… CONTINUE READING
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