Use of IgM enriched intravenous immunoglobulin (Pentaglobin) in bone marrow transplantation.

@article{Poynton1992UseOI,
  title={Use of IgM enriched intravenous immunoglobulin (Pentaglobin) in bone marrow transplantation.},
  author={Chris H Poynton and Simon K. Jackson and Christopher Fegan and R. A. Barnes and Joseph A. Whittaker},
  journal={Bone marrow transplantation},
  year={1992},
  volume={9 6},
  pages={451-7}
}
In a study of 63 allogeneic and autologous bone marrow transplants, patients were randomized to receive the IgM and IgA enriched intravenous immunoglobulin (IVIG) preparation (Pentaglobin). Pentaglobin has been postulated to have anti-endotoxin properties and one of the aims of the study was to measure endotoxin levels in these patients together with the clinical sequelae of infection. The anti-endotoxin effects of Pentaglobin were found to reside in the IgM fraction. Those patients who… CONTINUE READING