Use of IGK gene rearrangement analysis for clonality assessment of lymphoid malignancies: a single center experience.

@article{Mannu2011UseOI,
  title={Use of IGK gene rearrangement analysis for clonality assessment of lymphoid malignancies: a single center experience.},
  author={Claudia Mannu and Anna Gazzola and Francesco Bacci and Elena Sabattini and Carlo Sagramoso and Fernando Roncolato and Maura Rossi and Maria Antonella Laginestra and Maria Rosaria Sapienza and Claudio Agostinelli and Antonio De Leo and Milena Piccioli and Simona Righi and Patrizia Artioli and Luigi Chilli and Gianpaolo Da Pozzo and Giuseppe Andrea De Biase and Federica Sandri and Stefano A Pileri and Pier Paolo Piccaluga},
  journal={American journal of blood research},
  year={2011},
  volume={1 2},
  pages={
          167-74
        }
}
Diagnosis of B-non Hodgkin lymphomas (NHLs) is based on clinical, morphological and immunohistochemi-cal features. However, in up to 10-15% of cases, analysis of immunoglobulin heavy (IGH) or light (IGK/IGL) chains genes is required to discriminate between malignant and reactive lymphoid proliferations. In this study, we evaluated the feasibility and efficiency of IGK analysis in the routine diagnostic of B-cell lymphoproliferative disorders (B-LD) when applied to formalin-fixed paraffin… CONTINUE READING

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