Use of Histamine2-Antagonists for the Treatment of Verruca Vulgaris

@article{Fit2007UseOH,
  title={Use of Histamine2-Antagonists for the Treatment of Verruca Vulgaris},
  author={Kathy E. Fit and Patrick C. Williams},
  journal={Annals of Pharmacotherapy},
  year={2007},
  volume={41},
  pages={1222 - 1226}
}
Objective: To review the evidence for histamine2 (H2)-antagonists in the treatment of common warts. Data Sources: Relevant publications were identified through a systematic search of PubMed English-language literature using the MeSH terms and key words cimetidine, ranitidine, famotidine, nizatidine, histamine H2-antagonists, and warts. Additional articles were identified using the same key words in the Cochrane Database and International Pharmaceutical Abstracts. Systematic searches were… 

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References

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Cimetidine therapy for warts: a placebo-controlled, double-blind study.

Cimetidine therapy for recalcitrant warts in adults.

This study confirms that high-dose cimetidine therapy appears to be beneficial and safe in the treatment of recalcitrant warts in adults and further placebo-controlled studies are needed to determine its true efficacy.

Comparison of combination of cimetidine and levamisole with cimetidine alone in the treatment of recalcitrant warts

It is demonstrated that the combination of cimetidine with levamisole is more effective than cimetazine alone and is a highly effective therapy for the treatment of recalcitrant warts.

Treatment of viral warts with cimetidine: an open‐label study

The data suggests that cimetidine may be helpful in the treatment of viral warts in both adults and children and supports the need for a randomized controlled trial.

Cimetidine and Levamisole Versus Cimetidine Alone for Recalcitrant Warts in Children

The present study demonstrated that the combination of cimetidine with levamisole is more effective than cimentidine alone and is a highly effective therapy for the treatment of recalcitrant warts.

Cimetidine and warts.

A different experience with the use of cimetidine to treat common warts is reported and the need for placebo-controlled studies to assess the efficacy of this treatment is emphasized.

Cimetidine treatment for viral warts enhances IL-2 and IFN-gamma expression but not IL-18 expression in lesional skin.

It is suggested that cimetidine is an effective treatment for viral warts based on the decrease in IL-18 mRNA elicited by the drug, which might be expressed by keratinocytes infected with HPV.

Histamine type-2 receptor antagonist immune modulation. II. Cimetidine and ranitidine increase interleukin-2 production.

The effect of cimetidine and ranitidine on the production of interleukin-2 by mitogen-activated, normal murine spleen cells was studied in vitro and suggest that histamine type-2 receptor antagonists may have immunorestorative potential in clinical immunotherapy of IL-2 deficient states.