Use of Histamine2-Antagonists for the Treatment of Verruca Vulgaris

  title={Use of Histamine2-Antagonists for the Treatment of Verruca Vulgaris},
  author={Kathy E. Fit and Patrick C. Williams},
  journal={Annals of Pharmacotherapy},
  pages={1222 - 1226}
Objective: To review the evidence for histamine2 (H2)-antagonists in the treatment of common warts. Data Sources: Relevant publications were identified through a systematic search of PubMed English-language literature using the MeSH terms and key words cimetidine, ranitidine, famotidine, nizatidine, histamine H2-antagonists, and warts. Additional articles were identified using the same key words in the Cochrane Database and International Pharmaceutical Abstracts. Systematic searches were… 

A Novel Topical 2% Povidone–Iodine Solution for the Treatment of Common Warts: A Randomized, Double-Blind, Vehicle-Controlled Trial

Twice-daily topical povidone–iodine solution in the novel vehicle employed for this study is an effective, safe and easy-to-use treatment for common warts.

Comparison of the therapeutic efficacy of cimetidine and cryotherapy with placebo and cryotherapy in treatment of warts

This study showed that cimetidine is not more effective than placebo in treatment of warts.

Treatment of recalcitrant periungual warts with cimetidine in pediatrics

A 12-year-old girl with recalcitrant periungual warts, successfully treated with cimetidine for 4 months without subsequent recurrence and side effects is presented.

Commentary: A Novel Topical 2% Povidone-Iodine Solution for the Treatment of Common Warts: A Randomized, Double-Blind, Vehicle-Controlled Trial

Twenty-one patients aged 8 years and older were enrolled in Phase II clinical trial to assess the efficacy, safety, and tolerability of twice-daily application of a novel 2% topical povidone–iodine solution in a dimethyl sulfoxide vehicle for 12 weeks duration.

Mechanisms of allergic diseases

The aim is to provide excellent reviews on key aspects of allergic disease to those who research, treat, or manage allergic disease and to only claim credit commensurate with the extent of their participation in the activity.

Evolving role of immunotherapy in the treatment of refractory warts

The mechanism of action of these immunotherapeutic agents, along with their dosage, mode of administration, duration of use, expected outcomes and comparative efficacy, evidence for their use, and expected side effects, if any, are reviewed.

Treatment of Warts in Pediatrics: A Review

The goal of this paper is to review the different treatments that are beneficial and safe to use for warts in the pediatric population and break down the adverse effects, benefits, and efficacy of each of the options.

Update: Treatment of Cutaneous Viral Warts in Children

An update on research in the field of viral cutaneous wart therapies with a focus on pediatric patients is provided and safety issues and potential complications of therapy are addressed.

In-vitro and in-vivo evaluation of Cimetidine loaded mucoadhesive microspheres

Results are indicative of cimetidine as mucoadhesive microspheres for improving the oral bioavailability with controlled drug release and revealed that the optimized formulation M12 gave the highest AUC and T max.



Cimetidine therapy for warts: a placebo-controlled, double-blind study.

Cimetidine therapy for recalcitrant warts in adults.

This study confirms that high-dose cimetidine therapy appears to be beneficial and safe in the treatment of recalcitrant warts in adults and further placebo-controlled studies are needed to determine its true efficacy.

Comparison of combination of cimetidine and levamisole with cimetidine alone in the treatment of recalcitrant warts

It is demonstrated that the combination of cimetidine with levamisole is more effective than cimetazine alone and is a highly effective therapy for the treatment of recalcitrant warts.

Treatment of viral warts with cimetidine: an open‐label study

The data suggests that cimetidine may be helpful in the treatment of viral warts in both adults and children and supports the need for a randomized controlled trial.

Cimetidine and Levamisole Versus Cimetidine Alone for Recalcitrant Warts in Children

The present study demonstrated that the combination of cimetidine with levamisole is more effective than cimentidine alone and is a highly effective therapy for the treatment of recalcitrant warts.

Cimetidine and warts.

A different experience with the use of cimetidine to treat common warts is reported and the need for placebo-controlled studies to assess the efficacy of this treatment is emphasized.

Cimetidine treatment for viral warts enhances IL-2 and IFN-gamma expression but not IL-18 expression in lesional skin.

It is suggested that cimetidine is an effective treatment for viral warts based on the decrease in IL-18 mRNA elicited by the drug, which might be expressed by keratinocytes infected with HPV.

Histamine type-2 receptor antagonist immune modulation. II. Cimetidine and ranitidine increase interleukin-2 production.

The effect of cimetidine and ranitidine on the production of interleukin-2 by mitogen-activated, normal murine spleen cells was studied in vitro and suggest that histamine type-2 receptor antagonists may have immunorestorative potential in clinical immunotherapy of IL-2 deficient states.