Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.


In the present study, DNA-damage and clastogenic or aneugenic effects of genotoxic compounds were examined in a metabolically competent human cell line (HepG2 cells) using the micronucleus and the comet assays. Compounds with various action mechanisms were tested: direct mutagens such as 4-nitroquinoline-N-oxide (4-NQO) and methyl methanesulfonate (MMS) and… (More)


  • Presentations referencing similar topics