Use of Fresh and Cryopreserved Human Liver Slices in Toxicology with Special Reference to In vitro Induction of Cytochrome P450.

@article{Glckner1999UseOF,
  title={Use of Fresh and Cryopreserved Human Liver Slices in Toxicology with Special Reference to In vitro Induction of Cytochrome P450.},
  author={Reinhild Gl{\"o}ckner and Peter Steinmetzer and C Drobner and Dieter Mueller},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={1999},
  volume={13 4-5},
  pages={531-5}
}
Human liver slices were prepared with a Krumdieck slicer from macroscopically healthy surgical waste after partial hepatectomy. They were incubated without or with the addition of the inducer beta-naphthoflavone (BNF) (25 mum) either immediately after preparation (fresh slices) for up to 24 hours or after cryopreservation in liquid nitrogen (thawed slices) for up to 6 hours. Potassium concentration was well maintained in fresh and thawed slices over 24 and 6 hours, respectively, but at lower… CONTINUE READING

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