Use of Early Baculovirus Promoters for Continuous Expression and Efficient Processing of Foreign Gene Products in Stably Transformed Lepidopteran Cells

@article{Jarvis1990UseOE,
  title={Use of Early Baculovirus Promoters for Continuous Expression and Efficient Processing of Foreign Gene Products in Stably Transformed Lepidopteran Cells},
  author={Donald L. Jarvis and J. W. Fleming and Gerald R. Kovacs and Max D. Summers and Linda A. Guarino},
  journal={Bio/Technology},
  year={1990},
  volume={8},
  pages={950-955}
}
Baculoviruses are currently used as vectors for the transient high-level expression of foreign gene products in insect cells. In this study, we demonstrate that baculoviruses can also be made to continuously express a foreign gene product by using the promoter from IE1, an immediate early viral gene, to produce stably-transformed insect cells. This approach gave levels of foreign gene expression lower than those usually obtained with the lytic baculovirus expression vector system. Expression… CONTINUE READING

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