Use of Differential Scanning Calorimetry (DSC) to Study the Thermodynamics of DNA-Based Interactions and Nucleic Acid-Based Therapeutics

@inproceedings{Manyanga2016UseOD,
  title={Use of Differential Scanning Calorimetry (DSC) to Study the Thermodynamics of DNA-Based Interactions and Nucleic Acid-Based Therapeutics},
  author={Fidelis Manyanga and Alec Sithole and Ronald Eduardo Ch{\'a}vez Rivera and Nedim Karamehmedovic and Nicholas Joseph Martin},
  year={2016}
}
In the 1950’s, the research findings of James Watson, Francis Crick, Rosalind Franklin, and Maurice Wilkins led to the discovery of the deoxyribonucleic acid (DNA) double-helix conformation [1,2]. With DNA at their core, many nucleic acid based assays are used in pharmaceutical, biochemistry, biotechnology, molecular biology, target-based drug design, and other DNA-based technologies [3-7]. In addition, DNA is the molecular target of numerous anti-tumor drugs, anti-viral drugs, and several anti… CONTINUE READING

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