Use of Curcumin in Periodontal Inflammation

  title={Use of Curcumin in Periodontal Inflammation},
  author={Pulikottil Shaju Jacob and Sonia Nath and Sultan Os},
Periodontitis is a bacterial initiated but host modulated chronic infection that leads to destruction of the connective tissue supporting the teeth. Immune and inflammatory response directed against specific bacteria and its products become responsible for the local periodontal tissue loss in susceptible persons. Non-surgical therapy has been the mainstay of periodontal management with mechanical removal of plaque being the predominant method. However some individuals non responsive with only… 

Tables from this paper

Green Alternatives as Antimicrobial Agents in Mitigating Periodontal Diseases: A Narrative Review

This review concentrated on phytochemicals or herbal extracts that impact periodontal diseases by decreasing the formation of dental biofilms and plaques, preventing the proliferation of oral pathogens, and inhibiting bacterial adhesion to surfaces.

The effect of curcumin on growth and adherence of major microorganisms causing tooth decay

Background and objective: Streptococcus mutans and Lactobacillus acidophilus are bacteria producing tooth decay which by adhering to tooth surfaces contribute to its pathogenesis. By increasing

Design and In Vitro Evaluation of Curcumin Dental Films for the Treatment of Periodontitis

The study suggests that curcumin dental film is a potential drug delivery device for the topical treatment of periodontal diseases.

Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control

It may be concluded that curcumin mucoadhesive film showed promising results in reducing postoperative pain and swelling over a period of 1 week, hence showing its analgesic effect after periodontal surgeries.

Bioadhesive Matrix Tablets Loaded with Lipophilic Nanoparticles as Vehicles for Drugs for Periodontitis Treatment: Development and Characterization

The data demonstrate the ability of NLC to promote the penetration of CUR into the lipophilic domains of the mucosal membrane, while MTR can penetrate and permeate the mucological tissue, where it can perform a loco-regional antibacterial activity.

Anti-Inflammatory Therapies for Long Term auto Immune Diseases

New advances in understanding inflammatory signaling and its links to identification pathways, together with new medicine development, offer assure right here of translational biomedical examination.

Development, optimization and evaluation of curcumin loaded biodegradable crosslinked gelatin film for the effective treatment of periodontitis

The developed optimized Gelatin film was optimized to provide anticipated mucoadhesive strength, mechanical properties, folding endurance, and prolonged drug release over treatment duration, for successful application in the periodontitis.

The Effect of Curcumin (Turmeric) on Oral and Periodontal Diseases

Since turmeric has antimicrobial, Antioxidant and other useful properties, it is useful in dentistry also.

Review on Natural Excipients in the Formulation of Oral Fast Dissolving Films

The use of natural excipients such as polymers, plasticizers, flavoring agents, colorants and sweeteners for the formulation of oral fast dissolving films was more advantageous over syntheticexcipients.

Future prospects of systemic host modulatory agents in periodontal therapy

Periodontitis is an inflammatory disease caused by microbial infection that leads to destruction of supporting tissues of the teeth. The periodontal tissue destruction is a result of both microbial

Periodontal pharmacotherapy - an updated review.

A number of recent periodontal studies present some of the pharmacological agents, that are directed against bacteria or a host immune response, are often chosen as an adjunct treatment option, but none of these antimicrobials were established as 'a gold standard' in theperiodontal treatment.

4-Methoxycarbonyl Curcumin: A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation

It is demonstrated that a novel CMC (CMC 2.5: 4-methoxycarbonylCurcumin) has significant inhibitory effects, better than the parent compound curcumin, on proinflammatory cytokines and MMPs in in vitro, in cell culture, and in an animal model of periodontal inflammation.

Novel host response therapeutic approaches to treat periodontal diseases.

This review has sought to provide mechanistic overviews and clinical applications on the use of host modulatory therapeutic regimens for periodontal disease management by using gene therapy vectors to provide a longer-term delivery of tumor necrosis factor receptor antagonists at the periodontium.

Current concepts in periodontal pathogenesis.

The purpose of this paper is to review current thinking in periodontics with special reference to periodontal epidemiology, microbiology, and pathogenesis.

Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo.

Curcumin did not prevent alveolar bone resorption, but its potent anti-inflammatory effect suggests that it may have a therapeutic potential in periodontal diseases.

Host response modulation in the management of periodontal diseases.

After validation in long-term clinical trials, adjunctive host modulation therapy may prove advantageous in the management of periodontal diseases.

Antimicrobial peptides in periodontal innate defense.

    S. Gorr
    Biology, Medicine
    Frontiers of oral biology
  • 2012
The differential regulation of AMP expression in periodontal disease suggests that AMP panels, including up- and downregulated proteins, can be used in oral fluid diagnosis of periodontic disease and to monitor treatment outcome.

Anti-Inflammatory Activity of Curcumin in Macrophages Stimulated by Lipopolysaccharides from Porphyromonas gingivalis

The data suggest that curcumin can inhibit P. gingivalis LPS-induced cytokine expression, and that this could be due to the inhibition of the NF-ĸB pathway.

A Novel Chemically Modified Curcumin Reduces Severity of Experimental Periodontal Disease in Rats: Initial Observations

This initial study, on a novel triketonic zinc-binding CMC, indicates potential efficacy on inflammatory mediators and alveolar bone loss in experimental periodontitis and warrants future therapeutic and pharmacokinetic investigations.