Use of Curcumin in Periodontal Inflammation
@inproceedings{Jacob2014UseOC, title={Use of Curcumin in Periodontal Inflammation}, author={Pulikottil Shaju Jacob and Sonia Nath and Sultan Os}, year={2014} }
Periodontitis is a bacterial initiated but host modulated chronic infection that leads to destruction of the connective tissue supporting the teeth. Immune and inflammatory response directed against specific bacteria and its products become responsible for the local periodontal tissue loss in susceptible persons. Non-surgical therapy has been the mainstay of periodontal management with mechanical removal of plaque being the predominant method. However some individuals non responsive with only…
Tables from this paper
10 Citations
Green Alternatives as Antimicrobial Agents in Mitigating Periodontal Diseases: A Narrative Review
- 2023
Medicine, Biology
Microorganisms
This review concentrated on phytochemicals or herbal extracts that impact periodontal diseases by decreasing the formation of dental biofilms and plaques, preventing the proliferation of oral pathogens, and inhibiting bacterial adhesion to surfaces.
The effect of curcumin on growth and adherence of major microorganisms causing tooth decay
- 2017
Chemistry
Background and objective: Streptococcus mutans and Lactobacillus acidophilus are bacteria producing tooth decay which by adhering to tooth surfaces contribute to its pathogenesis. By increasing…
Design and In Vitro Evaluation of Curcumin Dental Films for the Treatment of Periodontitis
- 2017
Medicine
The study suggests that curcumin dental film is a potential drug delivery device for the topical treatment of periodontal diseases.
Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control
- 2019
Medicine
Journal of Indian Society of Periodontology
It may be concluded that curcumin mucoadhesive film showed promising results in reducing postoperative pain and swelling over a period of 1 week, hence showing its analgesic effect after periodontal surgeries.
Bioadhesive Matrix Tablets Loaded with Lipophilic Nanoparticles as Vehicles for Drugs for Periodontitis Treatment: Development and Characterization
- 2019
Biology
Polymers
The data demonstrate the ability of NLC to promote the penetration of CUR into the lipophilic domains of the mucosal membrane, while MTR can penetrate and permeate the mucological tissue, where it can perform a loco-regional antibacterial activity.
Anti-Inflammatory Therapies for Long Term auto Immune Diseases
- 2016
Biology, Medicine
New advances in understanding inflammatory signaling and its links to identification pathways, together with new medicine development, offer assure right here of translational biomedical examination.
Development, optimization and evaluation of curcumin loaded biodegradable crosslinked gelatin film for the effective treatment of periodontitis
- 2018
Materials Science
Drug development and industrial pharmacy
The developed optimized Gelatin film was optimized to provide anticipated mucoadhesive strength, mechanical properties, folding endurance, and prolonged drug release over treatment duration, for successful application in the periodontitis.
The Effect of Curcumin (Turmeric) on Oral and Periodontal Diseases
- 2017
Medicine
Since turmeric has antimicrobial, Antioxidant and other useful properties, it is useful in dentistry also.
Review on Natural Excipients in the Formulation of Oral Fast Dissolving Films
- 2016
Medicine
The use of natural excipients such as polymers, plasticizers, flavoring agents, colorants and sweeteners for the formulation of oral fast dissolving films was more advantageous over syntheticexcipients.
Synthesis, crystal structure, and Reactive Oxygen Species (ROS) inhibition of N– and O–linked triazole analogues of harmine
- 2022
Chemistry
Journal of Molecular Structure
60 References
Future prospects of systemic host modulatory agents in periodontal therapy
- 2013
Biology, Medicine
BDJ
Periodontitis is an inflammatory disease caused by microbial infection that leads to destruction of supporting tissues of the teeth. The periodontal tissue destruction is a result of both microbial…
Periodontal pharmacotherapy - an updated review.
- 2011
Medicine, Biology
Advances in medical sciences
A number of recent periodontal studies present some of the pharmacological agents, that are directed against bacteria or a host immune response, are often chosen as an adjunct treatment option, but none of these antimicrobials were established as 'a gold standard' in theperiodontal treatment.
4-Methoxycarbonyl Curcumin: A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation
- 2013
Biology, Medicine
Mediators of inflammation
It is demonstrated that a novel CMC (CMC 2.5: 4-methoxycarbonylCurcumin) has significant inhibitory effects, better than the parent compound curcumin, on proinflammatory cytokines and MMPs in in vitro, in cell culture, and in an animal model of periodontal inflammation.
Novel host response therapeutic approaches to treat periodontal diseases.
- 2007
Medicine, Biology
Periodontology 2000
This review has sought to provide mechanistic overviews and clinical applications on the use of host modulatory therapeutic regimens for periodontal disease management by using gene therapy vectors to provide a longer-term delivery of tumor necrosis factor receptor antagonists at the periodontium.
Current concepts in periodontal pathogenesis.
- 2004
Medicine
Dental update
The purpose of this paper is to review current thinking in periodontics with special reference to periodontal epidemiology, microbiology, and pathogenesis.
Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo.
- 2011
Medicine, Biology
Journal of periodontal research
Curcumin did not prevent alveolar bone resorption, but its potent anti-inflammatory effect suggests that it may have a therapeutic potential in periodontal diseases.
Host response modulation in the management of periodontal diseases.
- 2005
Medicine, Biology
Journal of clinical periodontology
After validation in long-term clinical trials, adjunctive host modulation therapy may prove advantageous in the management of periodontal diseases.
Antimicrobial peptides in periodontal innate defense.
- 2012
Biology, Medicine
Frontiers of oral biology
The differential regulation of AMP expression in periodontal disease suggests that AMP panels, including up- and downregulated proteins, can be used in oral fluid diagnosis of periodontic disease and to monitor treatment outcome.
Anti-Inflammatory Activity of Curcumin in Macrophages Stimulated by Lipopolysaccharides from Porphyromonas gingivalis
- 2008
Medicine, Biology
Pharmacology
The data suggest that curcumin can inhibit P. gingivalis LPS-induced cytokine expression, and that this could be due to the inhibition of the NF-ĸB pathway.
A Novel Chemically Modified Curcumin Reduces Severity of Experimental Periodontal Disease in Rats: Initial Observations
- 2014
Biology, Medicine
Mediators of inflammation
This initial study, on a novel triketonic zinc-binding CMC, indicates potential efficacy on inflammatory mediators and alveolar bone loss in experimental periodontitis and warrants future therapeutic and pharmacokinetic investigations.