Use of Conjugated Estrogens in Life-Threatening Gastrointestinal Bleeding in Hemodialysis Patients—A Review

  title={Use of Conjugated Estrogens in Life-Threatening Gastrointestinal Bleeding in Hemodialysis Patients—A Review},
  author={Gurpreet Lamba and Harneet Kaur and Sreedhar Adapa and Dhaval Shah and Bharat Malhotra and Shamudheen Mohammed Rafiyath and Keyur Thakar and Ana Cuesta Fernandez},
  journal={Clinical and Applied Thrombosis/Hemostasis},
  pages={334 - 337}
Hormonal agents (estrogen and progesterone) are being studied for their use in bleeding. This observance was initially explored in a patient with hereditary hemorrhagic telangiectasia (HHT) with epistaxis had variation in bleeding depending on her menstrual cycles.1 Thus, hormonal therapy was initially used in patients with HHT to control episodes of epistaxis.2 The literature on hormonal therapy in patients with life-threatening bleeding from gastrointestinal (GI) lesions is very limited… Expand
3 Citations
Application of Desmopressin and conjugated estrogens to reduce the volume of blood loss during arthroplsty of the hip joint in patients with end stage renal disease
The use of combination of conjugated estrogens and desmopressin in patients not suffering from kidney disease did not affect the amount of blood loss and the efficiency of the study was 27.9 %. Expand
Non-blood Product Agents for Bleeding Disorders
This chapter discussed the use of desmopressin, tranexamic acid, epsilon-aminocaproic acids, estrogens, and rVIIa for therapy of bleeding disorders. Expand
Diagnostik und Behandlung der hereditären hämorrhagischen Teleangiektasie
Die hereditare hamorrhagische Teleangiektasie (HHT; Morbus Osler-Weber-Rendu; Morbus Osler) ist mit einer weltweiten Pravalenz von 1:5000–8000 eine seltene Erkrankung der Kapillaren, bei der sichExpand


Conjugated estrogens for the management of bleeding associated with renal failure.
It is concluded that conjugated estrogens are an adequate alternative to cryoprecipitate or desmopressin for the treatment of bleeding associated with renal failure, especially when a longer duration of action is needed and immediate onset of the effect is not essential. Expand
Beneficial effect of low-dose transdermal estrogen on bleeding time and clinical bleeding in uremia.
  • J. Sloand, M. Schiff
  • Medicine
  • American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1995
Transdermal application of 17 beta-estradiol is a safe and effective means to reduce BT and clinical hemorrhage in patients with renal failure and prolonged BT in renal failure patients. Expand
Long‐term effect of hormonal therapy for bleeding gastrointestinal vascular malformations
Oestrogen-progesterone therapy stops bleeding in patients with severely bleeding gastrointestinal vascular malformations and this effect persists for a mean period of about 10 months. Expand
Treatment of bleeding gastrointestinal vascular malformations with oestrogen-progesterone
It is shown that oestrogen-progesterone is an effective treatment for severely bleeding gastrointestinal vascular malformations and no significant excess of side-effects was noted with the active agents. Expand
Estrogen-progesterone therapy for bleeding gastrointestinal telangiectasias in chronic renal failure. An uncontrolled trial.
The results of this trial indicate the need for controlled investigations of this type of hormonal therapy and suggest that estrogen or estrogen-progesterone therapy may control mucosal bleeding from telangiectasias in patients with hereditary hemorrhagic telANGiectasia. Expand
Does hormonal therapy have any benefit for bleeding angiodysplasia?
The findings do not support the use of hormonal therapy for bleeding from small intestinal angiodysplasia. Expand
Oral estrogens decrease bleeding time and improve clinical bleeding in patients with renal failure.
It is concluded that orally administered conjugated estrogens effectively improve the bleeding tendency in patients with chronic renal failure. Expand
Conjugated Estrogens for the Management of Gastrointestinal Bleeding Secondary to Uremia of Acute Renal Failure
A patient with acute renal failure and uncontrolled gastrointestinal bleeding was successfully treated with conjugated estrogens after failing desmopressin and octreotide therapy. Expand
Medical Therapy for Chronic Gastrointestinal Bleeding of Obscure Origin
In this long-term observational study, combination hormonal therapy was shown to stop rebleeding in patients with occult gastrointestinal bleeding of obscure origin. Expand
A multicenter, randomized, clinical trial of hormonal therapy in the prevention of rebleeding from gastrointestinal angiodysplasia.
Continuous estrogen-progestagen treatment is not useful in the prevention of rebleeding from gastrointestinal angiodysplasia. Expand