Use of Conjugated Estrogens in Life-Threatening Gastrointestinal Bleeding in Hemodialysis Patients—A Review

@article{Lamba2013UseOC,
  title={Use of Conjugated Estrogens in Life-Threatening Gastrointestinal Bleeding in Hemodialysis Patients—A Review},
  author={Gurpreet Lamba and Harneet Kaur and Sreedhar Adapa and Dhaval Shah and Bharat Malhotra and Shamudheen Mohammed Rafiyath and Keyur Thakar and Ana Cuesta Fernandez},
  journal={Clinical and Applied Thrombosis/Hemostasis},
  year={2013},
  volume={19},
  pages={334 - 337}
}
Hormonal agents (estrogen and progesterone) are being studied for their use in bleeding. This observance was initially explored in a patient with hereditary hemorrhagic telangiectasia (HHT) with epistaxis had variation in bleeding depending on her menstrual cycles.1 Thus, hormonal therapy was initially used in patients with HHT to control episodes of epistaxis.2 The literature on hormonal therapy in patients with life-threatening bleeding from gastrointestinal (GI) lesions is very limited… Expand
3 Citations
Application of Desmopressin and conjugated estrogens to reduce the volume of blood loss during arthroplsty of the hip joint in patients with end stage renal disease
TLDR
The use of combination of conjugated estrogens and desmopressin in patients not suffering from kidney disease did not affect the amount of blood loss and the efficiency of the study was 27.9 %. Expand
Non-blood Product Agents for Bleeding Disorders
TLDR
This chapter discussed the use of desmopressin, tranexamic acid, epsilon-aminocaproic acids, estrogens, and rVIIa for therapy of bleeding disorders. Expand
Diagnostik und Behandlung der hereditären hämorrhagischen Teleangiektasie
Die hereditare hamorrhagische Teleangiektasie (HHT; Morbus Osler-Weber-Rendu; Morbus Osler) ist mit einer weltweiten Pravalenz von 1:5000–8000 eine seltene Erkrankung der Kapillaren, bei der sichExpand

References

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TLDR
It is concluded that conjugated estrogens are an adequate alternative to cryoprecipitate or desmopressin for the treatment of bleeding associated with renal failure, especially when a longer duration of action is needed and immediate onset of the effect is not essential. Expand
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TLDR
Transdermal application of 17 beta-estradiol is a safe and effective means to reduce BT and clinical hemorrhage in patients with renal failure and prolonged BT in renal failure patients. Expand
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TLDR
Oestrogen-progesterone therapy stops bleeding in patients with severely bleeding gastrointestinal vascular malformations and this effect persists for a mean period of about 10 months. Expand
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TLDR
It is shown that oestrogen-progesterone is an effective treatment for severely bleeding gastrointestinal vascular malformations and no significant excess of side-effects was noted with the active agents. Expand
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TLDR
The results of this trial indicate the need for controlled investigations of this type of hormonal therapy and suggest that estrogen or estrogen-progesterone therapy may control mucosal bleeding from telangiectasias in patients with hereditary hemorrhagic telANGiectasia. Expand
Does hormonal therapy have any benefit for bleeding angiodysplasia?
TLDR
The findings do not support the use of hormonal therapy for bleeding from small intestinal angiodysplasia. Expand
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TLDR
It is concluded that orally administered conjugated estrogens effectively improve the bleeding tendency in patients with chronic renal failure. Expand
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TLDR
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TLDR
In this long-term observational study, combination hormonal therapy was shown to stop rebleeding in patients with occult gastrointestinal bleeding of obscure origin. Expand
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TLDR
Continuous estrogen-progestagen treatment is not useful in the prevention of rebleeding from gastrointestinal angiodysplasia. Expand
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