Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere.

  title={Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere.},
  author={Claudine S. Bonder and S. R. Clark and M. Ursula Norman and Pauline Johnson and Paul Kubes},
  volume={107 12},
Localization of circulating lymphocytes to a site of inflammation is paramount for the development and maintenance of an immune response. In vitro studies using cell lines have previously demonstrated that rolling and adhesion of lymphocytes on endothelium requires CD44 interactions with hyaluronan (HA). To date, whether CD44 has a role in mediating CD4(+)-polarized T-helper 1 (Th1) and Th2 lymphocyte interactions with the endothelium in vivo is yet to be determined. In this study we used… CONTINUE READING

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