Use of CD137 up-regulation to identify T cell receptors specifically reactive with mutated tumor associated antigens from tumor infiltrating lymphocytes

@inproceedings{Parkhurst2015UseOC,
  title={Use of CD137 up-regulation to identify T cell receptors specifically reactive with mutated tumor associated antigens from tumor infiltrating lymphocytes},
  author={Maria R. Parkhurst and Alena Gros and Pasetto Anna and Eric Tran and Jessica S. Crystal and Todd D. Prickett and Paul F. Robbins and Steven A Rosenberg},
  year={2015}
}
Background The adoptive transfer of tumor infiltrating lymphocytes (TIL) can mediate the regression of metastatic melanoma. In addition, the adoptive transfer of lymphocytes genetically modified to express tumor reactive T cell receptors (TCRs) can mediate tumor regression. Many T cells from TIL recognize mutated antigens expressed only on the autologous… CONTINUE READING