Use of Bupropion in Combination with Serotonin Reuptake Inhibitors

@article{Zisook2006UseOB,
  title={Use of Bupropion in Combination with Serotonin Reuptake Inhibitors},
  author={Sidney Zisook and Augustus John Rush and Barbara R. Haight and Dawn C. Clines and Carol B. Rockett},
  journal={Biological Psychiatry},
  year={2006},
  volume={59},
  pages={203-210}
}
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Aripiprazole augmentation is at least comparable to bupropion augmentation in combination with SSRI in terms of efficacy and tolerability in patients with MDD, according to the first randomized, prospective, open-label, direct comparison study.
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The addition of bupropion at higher doses appears to be more effective approach in comparison with amantadine, providing empirical support for conducting a further study on comparing different add-on strategies for treating drug induced SD.
Sexual dysfunction during treatment with serotonergic and noradrenergic antidepressants: Clinical description and the role of the 5-HTTLPR
  • J. Strohmaier, S. Wüst, M. Rietschel
  • Psychology, Medicine
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2011
TLDR
In GENDEP, rates of reported SD during treatment were lower than those described in previous reports, and there was no apparent effect of the 5-HTTLPR on the observed decline in SD.
Advances in the treatment of depression
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Anecdotal reports indicate bupropion may lower inflammatory mediators such as tumor necrosis factor-α, may lower fatigue in cancer and may help reduce concentration problems.
[Combining antidepressants: a useful strategy for therapy resistant depression?].
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The distinct knowledge of available antidepressant combination strategies may help to increase response--as well as remission rates in therapy resistant depression, however, further research is urgently needed to determine relative efficacy.
The Noradrenergic Action in Antidepressant Treatments: Pharmacological and Clinical Aspects
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An updated overview of the main pharmacological and clinical aspects of antidepressant classes that, partially or selectively, act on the noradrenergic systems is provided.
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With conservative dosing and close monitoring, combinations of SRIs with bupropion in this uncontrolled clinical series appeared to be safe and often more effective than monotherapy.
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