Use of Bupropion in Combination with Serotonin Reuptake Inhibitors

@article{Zisook2006UseOB,
  title={Use of Bupropion in Combination with Serotonin Reuptake Inhibitors},
  author={Sidney Zisook and A. John Rush and Barbara R. Haight and Dawn C. Clines and Carol B. Rockett},
  journal={Biological Psychiatry},
  year={2006},
  volume={59},
  pages={203-210}
}
Incomplete symptom remission and sexual side effects are common problems for which bupropion often is added to treatment with selective serotonin and serotonin-norepinephrine reuptake inhibitors (SSRIs and SNRIs) for patients with major depressive disorder (MDD). This article reviews the literature on combining bupropion with SSRIs or SNRIs. We used MEDLINE to select studies that included patients diagnosed with MDD treated with any combination of bupropion and an SSRI or SNRI, either to… Expand
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  • 2011
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References

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Combining serotonin reuptake inhibitors and bupropion in partial responders to antidepressant monotherapy.
TLDR
With conservative dosing and close monitoring, combinations of SRIs with bupropion in this uncontrolled clinical series appeared to be safe and often more effective than monotherapy. Expand
Bupropion and sertraline combination treatment in refractory depression
TLDR
Four treatment- refractory patients who presented for clinical care are described, in which the combination of bupropion and sertraline was effective for a major depressive episode, suggesting synergism of its two distinct antidepressant mechanisms involving serotonergic, dopaminergic and noradrenergic systems. Expand
A Prospective Trial of Bupropion SR Augmentation of Partial and Non-Responders to Serotonergic Antidepressants
TLDR
This prospective, open-label trial supports the use of bupropion SR in the augmentation of SSRIs and venlafaxine in patients with inadequate response to selective serotonin reuptake inhibitors. Expand
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TLDR
Bupropion administration may be a safe and effective method of treating SRI-induced sexual dysfunction and placebo-controlled, double-blind studies are needed. Expand
Bupropion Treatment of Serotonin Reuptake Antidepressant-Associated Sexual Dysfunction
TLDR
Bupropion may be a pharmacologic option for treating SRI-associated sexual dysfunction, though controlled clinical trials are needed. Expand
Serotonin syndrome induced by a combination of bupropion and SSRIs.
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TLDR
A 62-year-old woman treated with therapeutic dosages of bupropion and sertraline for depression for the previous 3 weeks presented with upper extremity myoclonic jerks, clumsiness, and gait difficulties with fluctuating symptoms of confusion, forgetfulness, and the alternation of agitation and lethargy, and was started on cyproheptadine and clonazepam. Expand
Combining bupropion SR with venlafaxine, paroxetine, or fluoxetine: a preliminary report on pharmacokinetic, therapeutic, and sexual dysfunction effects.
TLDR
Bupropion had an effect on the pharmacokinetics of venlafaxine but not those of the SSRIs. Expand
Treatment of Resistant Depression by Adding Noradrenergic Agents to Lithium Augmentation of SSRIs
TLDR
Second-line augmentation with bupropion was better tolerated than desipramine and may be a viable option to optimize recovery in depressed patients with a partial response to lithium augmentation of SSRIs. Expand
A placebo-controlled trial of bupropion SR as an antidote for selective serotonin reuptake inhibitor-induced sexual dysfunction.
TLDR
Bupropion SR, as an effective antidote to SSRI-induced sexual dysfunction, produced an increase in desire to engage in sexual activity and frequency of engaging inSexual activity compared with placebo. Expand
Bupropion-Sustained Release as a Treatment for SSRI-Induced Sexual Side Effects
TLDR
All sexual side effects improved in response to bupropion SR in both men and women with no differential effect on any one sexual side effect. Expand
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