Use of Benzodiazepines during Pregnancy, Labour and Lactation, with Particular Reference to Pharmacokinetic Considerations

@article{Kanto2012UseOB,
  title={Use of Benzodiazepines during Pregnancy, Labour and Lactation, with Particular Reference to Pharmacokinetic Considerations},
  author={J. Kanto},
  journal={Drugs},
  year={2012},
  volume={23},
  pages={354-380}
}
  • J. Kanto
  • Published 2012
  • Medicine
  • Drugs
  • SummaryKnowledge of the pharmacokinetic properties of the benzodiazepines is playing an increasingly important role in their use during pregnancy, labour and lactation. All of the benzodiazepine derivatives are lipophilic, undissociated agents which readily penetrate membranes. Thus, they exhibit rapid placental transfer with significant fetal uptake of the drug.In the first trimester of pregnancy there is seldom a clear indication for the use of benzodiazepines. In late pregnancy and at… CONTINUE READING

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