Use of Benzodiazepines during Pregnancy, Labour and Lactation, with Particular Reference to Pharmacokinetic Considerations

@article{Kanto2012UseOB,
  title={Use of Benzodiazepines during Pregnancy, Labour and Lactation, with Particular Reference to Pharmacokinetic Considerations},
  author={J. Kanto},
  journal={Drugs},
  year={2012},
  volume={23},
  pages={354-380}
}
SummaryKnowledge of the pharmacokinetic properties of the benzodiazepines is playing an increasingly important role in their use during pregnancy, labour and lactation. All of the benzodiazepine derivatives are lipophilic, undissociated agents which readily penetrate membranes. Thus, they exhibit rapid placental transfer with significant fetal uptake of the drug.In the first trimester of pregnancy there is seldom a clear indication for the use of benzodiazepines. In late pregnancy and at… Expand
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References

SHOWING 1-10 OF 123 REFERENCES
Clinical Pharmacokinetics of Diazepam
Passage of diazepam and desmethyldiazepam into breast milk.
  • R. Brandt
  • Chemistry, Medicine
  • Arzneimittel-Forschung
  • 1976
Clinical Pharmacokinetics in Neonates
USE OF BENZODIAZEPINES IN THE MANAGEMENT OF ECLAMPSIA
The disposition kinetics of diazepam in pregnant women at parturition
A study of the plasma concentrations of lorazepam in mother and neonate.
Diazepam in Early Human Pregnancy
Transfer of free and conjugated oxazepam across the human placenta
...
1
2
3
4
5
...