Use of BOP-Cl in the presence of Boc-amino monothioacids for the thioacylation of imino acid residues.

@article{Le1996UseOB,
  title={Use of BOP-Cl in the presence of Boc-amino monothioacids for the thioacylation of imino acid residues.},
  author={Hung Thanh Le and J{\'e}r{\^o}me Gallard and Michel Mayer and Eric Guittet and Robert J Michelot},
  journal={Bioorganic & medicinal chemistry},
  year={1996},
  volume={4 12},
  pages={2201-9}
}
BOP-Cl was found to be an efficient coupling reagent for the introduction of thiopeptide bonds on imino acid residues (Pro, Sar). Boc-amino monothioacids were coupled at moderate temperature (0 degree C-RT) with fair yields and with retained optical purity. The mechanism of the coupling reaction is discussed.