Use of Atypical Antipsychotics in the Treatment of Autistic Disorder

@article{Stachnik2007UseOA,
  title={Use of Atypical Antipsychotics in the Treatment of Autistic Disorder},
  author={Joan M. Stachnik and Cheryl L Nunn-Thompson},
  journal={Annals of Pharmacotherapy},
  year={2007},
  volume={41},
  pages={626 - 634}
}
Objective: To review clinical trials and reports describing the efficacy and safety of atypical antipsychotics (olanzapine, ziprasidone, quetiapine, aripiprazole) in the treatment of autistic or other pervasive developmental disorders. Data Sources: English-language publications from the MEDLINE database (1966–February 2007) including clinical trials, case reports, and retrospective series were reviewed. Study Selection and Data Extraction: Relevant data were extracted from studies of selected… 

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References

SHOWING 1-10 OF 68 REFERENCES

Second-generation antipsychotic medications in children and adolescents.

Evidence suggests that second-generation antipsychotics are efficacious in the treatment of psychosis, bipolar disorders, pervasive developmental disorders, and Tourette's Disorder, and are potentially useful in mental retardation, conduct disorder, and severe attention deficit hyperactivity disorder.

Risperidone in children with autism and serious behavioral problems.

Risperidone was effective and well tolerated for the treatment of tantrums, aggression, or self-injurious behavior in children with autistic disorder and the benefit was maintained at six months.

Olanzapine versus haloperidol in children with autistic disorder: an open pilot study.

The findings suggest that olanzapine is a promising treatment for children with autistic disorder and further placebo-controlled and long-term studies of olanZapine in autistic disorder are required.

Open-Label Study of Olanzapine in Children with Pervasive Developmental Disorder

Olanzapine was a relatively safe medication in children, its clinical relevance in children with pervasive developmental disorder may be limited, and three children showed extrapyramidal symptoms that disappeared after the dose was lowered.

Aripiprazole use in individuals with intellectual disability and psychotic or behavioural disorders: a case series

Aripiprazole was well tolerated and effective in each of the cases and appears to be a safe and efficacious alternative in the management of patients with both intellectual disabilities and schizophrenia.

Treating Functional Impairment of Autism with Selective Serotonin-Reuptake Inhibitors

Benefits with SSRIs in treating functional impairments in autism have been observed and current evidence does not support selection of one SSRI over another for any impairment associated with autism.

Quetiapine in nine youths with autistic disorder.

The data suggest that quetiapine may not be a particularly effective agent in the treatment of adolescent patients with AD, and it seems reasonable that they be conducted with more rigor, less treatment-resistant cohorts, and, possibly, a different dosing strategy.

A retrospective analysis of quetiapine in the treatment of pervasive developmental disorders.

Quetiapine was modestly effective for maladaptive behavior in patients with a PDD.

The effect of a switch to ziprasidone in an adult population with autistic disorder: chart review of naturalistic, open-label treatment.

In adults with autism, a switch to ziprasidone from other atypical antipsychotics appears to have the potential for maintaining beneficial effect on behavior while improving major health indices including weight and lipid levels.

Olanzapine treatment of children, adolescents, and adults with pervasive developmental disorders: an open-label pilot study.

Preliminary results suggest that olanzapine may be an effective and well tolerated drug in targeting core and related symptoms of PDDs in children, adolescents, and adults.
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