Use of Artificial Sputum Medium to Test Antibiotic Efficacy Against Pseudomonas aeruginosa in Conditions More Relevant to the Cystic Fibrosis Lung

@inproceedings{Kirchner2012UseOA,
  title={Use of Artificial Sputum Medium to Test Antibiotic Efficacy Against Pseudomonas aeruginosa in Conditions More Relevant to the Cystic Fibrosis Lung},
  author={Sebastian Kirchner and Joanne L. Fothergill and Elli A. Wright and Chloe E. James and Eilidh Mowat and Craig Winstanley},
  booktitle={Journal of visualized experiments : JoVE},
  year={2012}
}
There is growing concern about the relevance of in vitro antimicrobial susceptibility tests when applied to isolates of P. aeruginosa from cystic fibrosis (CF) patients. Existing methods rely on single or a few isolates grown aerobically and planktonically. Predetermined cut-offs are used to define whether the bacteria are sensitive or resistant to any given antibiotic. However, during chronic lung infections in CF, P. aeruginosa populations exist in biofilms and there is evidence that the… CONTINUE READING
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