Use of AC impedance analysis to study membrane changes related to acid secretion in amphibian gastric mucosa.

@article{Clausen1983UseOA,
  title={Use of AC impedance analysis to study membrane changes related to acid secretion in amphibian gastric mucosa.},
  author={Chris Clausen and Terry E. Machen and Jared M. Diamond},
  journal={Biophysical journal},
  year={1983},
  volume={41 2},
  pages={167-78}
}
We have applied transepithelial AC impedance techniques to gastric mucosa to reconcile ultrastructural and electrophysiological findings about gastric acid secretion and the mucosal barrier. By fitting impedance data measured at different HCl secretion rates to equivalent circuit models, we extracted capacitances and resistances (as measures of membrane area and ionic conductance, respectively) for the apical and basolateral membranes. The impedance measurements were found to be incompatible… CONTINUE READING

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