Use of 5-fluorodeoxycytidine and tetrahydrouridine to exploit high levels of deoxycytidylate deaminase in tumors to achieve DNA- and target-directed therapies.

@article{Mekras1984UseO5,
  title={Use of 5-fluorodeoxycytidine and tetrahydrouridine to exploit high levels of deoxycytidylate deaminase in tumors to achieve DNA- and target-directed therapies.},
  author={J A Mekras and David A. Boothman and L. M. Luengo P{\'e}rez and Shaun Greer},
  journal={Cancer research},
  year={1984},
  volume={44 6},
  pages={2551-60}
}
In view of the 20- to 80-fold elevation of deoxycytidine-5'-phosphate (dCMP) deaminase in many human malignant tumors, we have utilized 5-fluorodeoxycytidine ( FdCyd ) coadministered with tetrahydrouridine ( H4Urd ) as a combination of antitumor agents against two murine solid tumors which possess high levels of dCMP deaminase. This approach is based on our past studies in which we demonstrated that FdCyd is an excellent substrate for mammalian 2'-deoxycytidine kinase, and that H4Urd increases… CONTINUE READING
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The effect of inhibition of cytidine deaminase by tetrahydrouridineon the utilization of deoxycytidineand 5-bromodeoxycytidine for DNA synthesis

  • G. Cooper, S. Gréer
  • Md. Pharmacd.,
  • 1973
Highly Influential
7 Excerpts

HSV type 2 induced pyrmidinenucleosidekinase: enzymatic basis for the selective antiherpetic effect of 5-halogenatedanalogs of deoxycytidine

  • M. Dooersen, S. Gréer
  • Biochemistry
  • 1978
Highly Influential
5 Excerpts

Phosphorylation of 5-hatogenated deoxycytidine analogs by deoxycytidine kinase

  • G. Cooper, S. Gréer
  • Md. Pharmacd.,
  • 1973
Highly Influential
6 Excerpts

The modulation of the thymidmetriphosphate pool of Chinesehamster cete by dCMP deaminase and UDPreducÃ-ase

  • B. Robert de Saint Vincent, M. Dechamps, G. Buttin
  • J. Biol. Chem.,
  • 1980
Highly Influential
3 Excerpts

The regulatory influence of altosteric effectors on deoxycytidylate deaminases.Curr

  • F. Maley, G. Maley
  • Top. Cell. Regul.,
  • 1972
Highly Influential
4 Excerpts

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