Use of 3-amino-1,2,4-triazole to reduce body catalase activity in cancer studies.

Heim, Appleman, and Pyfrom (1~) first showed that injection of the herbicide 3-amino-l,~,4triazole (AT) strikingly reduced the catalase activity of the liver, but not of the erythrocyte. This has since been amply confirmed (6, 13, 18), and it has been shown (6, 18) that AT per se is not an inhibitor of catalase but will, upon incubation in vitro, reduce the… CONTINUE READING