Use of 2-nitroimidazoles as bioreductive markers for tumour hypoxia.

  title={Use of 2-nitroimidazoles as bioreductive markers for tumour hypoxia.},
  author={Richard J Hodgkiss},
  journal={Anti-cancer drug design},
  volume={13 6},
Tumour hypoxia is thought to contribute to some failures of radiotherapy to achieve local control. Polarographic measurements of tumour oxygenation have been shown to predict clinical response to radiotherapy and patient survival. Hypoxia is also involved in many common types of normal tissue morbidity. However, at present there is no widely used method of measuring hypoxia in the clinic, or for individualizing therapy on the basis of tumour or tissue oxygenation. The bioreductive metabolism of… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 30 extracted citations

In vivo 19F magnetic resonance spectroscopy and chemical shift imaging of tri-fluoro-nitroimidazole as a potential hypoxia reporter in solid tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2007
View 10 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…