Use of 2-nitroimidazoles as bioreductive markers for tumour hypoxia.

@article{Hodgkiss1998UseO2,
  title={Use of 2-nitroimidazoles as bioreductive markers for tumour hypoxia.},
  author={Richard J Hodgkiss},
  journal={Anti-cancer drug design},
  year={1998},
  volume={13 6},
  pages={687-702}
}
Tumour hypoxia is thought to contribute to some failures of radiotherapy to achieve local control. Polarographic measurements of tumour oxygenation have been shown to predict clinical response to radiotherapy and patient survival. Hypoxia is also involved in many common types of normal tissue morbidity. However, at present there is no widely used method of measuring hypoxia in the clinic, or for individualizing therapy on the basis of tumour or tissue oxygenation. The bioreductive metabolism of… CONTINUE READING

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