Use of 11 C-MPDX and PET to Study Adenosine A 1 Receptor Occupancy by Nonradioactive Agonists and Antagonists

@inproceedings{Paul2014UseO1,
  title={Use of 11 C-MPDX and PET to Study Adenosine A 1 Receptor Occupancy by Nonradioactive Agonists and Antagonists},
  author={Soumen Paul and Shivashankar Khanapur and Jurgen W. A. Sijbesma and Kiichi Ishiwata and Philip H. Elsinga and Peter Meerlo and Rudi A. J. O. Dierckx and Aren van Waarde},
  year={2014}
}
Adenosine A1 receptors (A1Rs) in human and rodent brains can be visualized with the radioligand 8-dicyclopropylmethyl-1-11C-methyl3-propylxanthine (11C-MPDX) and PET. Here we investigated whether A1R occupancy by nonradioactive agonists and antagonists can be assessed with this technique. Methods: Small-animal PET scans with arterial blood sampling were obtained for 4 groups of isoflurane-anesthetized Wistar rats: controls (n 5 7); pretreated with a centrally active A1R agonist, N6… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 26 references

adenosine receptor agonists and their potential therapeutic applications

  • E Elzein, A ZablockiJ.
  • Expert Opin Investig Drugs
  • 2008
1 Excerpt

Similar Papers

Loading similar papers…